Borderline Personality Disorder
Funds - From the National Institute of Mental Health (NIMH)
Jim Breiling, Ph.D.
National Institute of Mental Health
6101 Executive Blvd., Room 6-179
Bethesda, MD 20892-9651
(Express or Courier Service: Rockville, MD 20852)
E-mail: jbreilin@mail.nih.gov
Voice: 301-443-3527
Fax: 301-443-4611
Funds
May 18, 2004
Below is the NIMH Crisp blurb on the first of a series of new grant fundings
on or highly relevant to borderline personality. This endeavor of Ken
Kendler brings a leading investigator to the study of personality disorders,
seeks understanding of the co-occurrence of disorders, and proposes to use
state of the art psychometric methods for the development of scales for
disorders. On all counts, a very welcome and important contribution to the
research endeavor. -- Jim Breiling
Grant Number: 1R01MH068643-01A1
PI Name: KENDLER, KENNETH S.
PI Email: kendler@hsc.vcu.edu <mailto:kendler@hsc.vcu.edu>
PI Title: PROFESSOR
Project Title: Axis I & Axis II Psychiatric Disorders in Norwegian Twin
Abstract: DESCRIPTION (provided by applicant): Personality (or axis II)
disorders are common, disabling and highly co-morbid with important axis I
psychiatric disorders such as major depression and anxiety disorders as well
as alcohol abuse/dependence. Personality disorders (PDs) aggregate in families, and existing twin studies suggest this familial aggregation is due
partly to genetic factors. However these were based on modest-sized clinical
samples or self-report questionnaires and have not been confirmed by an
interview-based epidemiologic twin study of PDs. The goal of this application is to conduct detailed analysis of a population-based study of
young adult twins in Norway assessed using personal interviews for the
lifetime history of both major axis I psychiatric and substance use disorders and all axis II disorders. Data collection -- supported from
Norwegian sources --is now 94% complete, and will be finished by 9/30/03
resulting in 1,400 complete twin pairs. We will conduct an extensive series
of analyses on this rich data set using both standard and recently developed
statistical tools. Aims include: i) examine and correct for attrition effects in the registry; ii) apply both factor and IRT models to generate
empirical PD scales; iii) conducting univariate twin analyses to clarify the
etiologic role of genetic, shared-environmental and individual specific
environment factors for personality disorder traits (PDTs); iv) performing
multivariate twin analyses to understand the sources of covariation between
both individual PDTs and PD clusters; v) examining a series of theory-driven
bivariate twin analyses to determine the degree to which selected pairs of
axis I disorders and PDTs reflect the similar or distinct genetic and
environmental risk factors such as Major Depression (MD) and Depressive and
Borderline PD, Social phobia and Avoidant PD, and Alcohol Abuse/Dependence
and Antisocial PD; vi) examine etiologic links between PDs and prospectively
collected data on pregnancy and birth complications and vii) attempt to
replicate key findings emerging from an on-going study of axis I Disorders
in the Virginia Twin Registry. This study has the capacity to address several key and largely unanswered empirical questions about
PDs, the answers to which will be critical for proposed revisions in DSM-V.
Thesaurus Terms:
There are no thesaurus terms on file for this project.
Institution: VIRGINIA COMMONWEALTH UNIVERSITY
RICHMOND, VA 232980568
Fiscal Year: 2004
Department: PSYCHIATRY
Project Start: 18-MAY-2004
Project End: 29-FEB-2008
ICD: NATIONAL INSTITUTE OF MENTAL HEALTH
IRG: BGES
May 24, 2004
On June 1st, Michael McCloskey, a junior colleague of Emil Coaccaro, will
get NIMH research support through a 2nd small grant (R03). While the clinical disorder of primary concern in this research is intermittent
explosive disorder (IED), the CRISH abstract below points up the relevance
to other disorders, including borderline personali disorder, and so this
grant is included in the results of a CRISP search for "borderline personality disorder" grants.
I hope for five, possibly more, borderline pd research grant awards before
the end of the current (2004) fiscal year on September 20. Assuming five
more, that will take the number of CRISP hits for "borderline personality
disorder" research grants in 2004 to 47 For five yeras ago (1999) there are
19 hits, and for 10 years ago (1994) there are 8 hits for "borderline personality disorder" research grants. So, every 5 years the number of
CRISP "hits" for borderline pd research grants more than doubles.
-- Jim Breiling
Grant Number: 1R03MH069764-01A1
PI Name: MCCLOSKEY, MICHAEL S.
PI Email: mmcclosk@yoda.bsd.uchicago.edu
<mailto:mmcclosk@yoda.bsd.uchicago.edu>
PI Title:
Project Title: Emotional Information Processing & IED: An fMRI Study
Abstract: The specific aim of the proposed project is to examine the relationship between neuroanatomical pathways and emotional information
processing deficits among individuals with Intermittent Explosive Disorder
(lED). To accomplish this goal. Two groups of individuals: 16 participants
with lED and 16 participants who are free of any clinical psychopathology,
will be asked to complete two tasks of emotional information processing (the
emotional counting stroop and the emotional faces task) during a one-hour
functional imaging session. Both tasks will be presented using a block
design. Tasks will be counterbalanced across subjects. The emotional counting stroop task will consist of 1-4 words presented on a screen, to
which the subject identifies how many words were shown. Four types of words
are used: positive (e.g. happy, puppy), neutral (e.g. sink, chair), general
negative (e.g. vomit, regret) and anger (e.g. fury, idiot). Words were
selected based on previous research. Pilot research by the authors suggest
that individuals with lED are slower and less accurate when anger words are
shown as compared to neutral words. During the emotional faces task,
participants will intermittently be shown faces with angry, neutral, fearful, or happy expressions. During the first two runs they will be asked
to identify the gender of the face presented using two 2-button response
panels on their right hand. During the latter two runs participants will be
asked to note the emotional expression of the pictures, but will not be
asked to make a response. Past research has shown that individuals with a
number of clinical disorders (e.g. Borderline Personality Disorder, Major
Depression) exhibit an impaired ability to identify some types of emotional
faces. Participants will then identify the emotional faces outside of the
fMRI environment. Recently it has been demonstrated that lED patients are
less accurate in identifying emotional faces than control subjects. It is
hypothesized that lED subjects will (1) be less accurate at the emotional
stroop tasks than control subjects when anger words are presented, (2) be
less accurate at identifying emotional faces than control subjects, and (3)
show a differential pattern of brain activation to emotional faces and words
including increased amygdala activation for fear words and faces and
decreased orbitofrontal activity for anger words and faces.
Thesaurus Terms:
emotion, mood disorder, neural information processing, neuroanatomy amygdala, anger, brain electrical activity, face expression, prefrontal lobe/cortex
behavioral /social science research tag, clinical research, functional
magnetic resonance imaging, human subject, patient oriented research, psychological test
Institution: UNIVERSITY OF CHICAGO
5801 S ELLIS AVE
CHICAGO, IL 60637
Fiscal Year: 2004
Department: PSYCHIATRY
Project Start: 01-JUN-2004
Project End: 31-MAY-2005
ICD: NATIONAL INSTITUTE OF MENTAL HEALTH
IRG: ZMH1
June 9, 2004
Eric Fertuck, a most able and promising junior investigator who worked for
the BPDRFoundation when we had the first New Directions conference at Rockefeller in 2000, and who now works with Barbara Stanley, has received a
NIMH grant through a NIMH T32 for his research on neuro and social cognition
in BPD on the basis of a priority score rate in the outstanding range. The
range of his expertise is reflected in his role as a co-investigator on the
Foundation funded treatment evaluation at Cornell.
June 15, 2004
The NIMH director has approved paying 5 grants for new borderline pd
research. This makes for a total of 12 new borderline personality disorder
grant awards this fiscal year. That's more new grant awards than there were
grant awards (new and continuing) just 10 years ago, and since junior
investigators are the future of research, it is of cheer that there very
likely have been more new grants to junior investigators this year than in
any previous year.
July 26, 2004
Below are that titles and web addresses for three new solicitations of grant
applications. The first, for K24 grant support, explicitly provides for
mentoring of junior investigators, a critical need for developing the next
generation of BPD clinical researchers. The second provides for grant
support for research relating to Barbara Stanley's question about stigma
concerning BPD. The third provides grant support for drug development.
-- Jim Breiling
PA-04-107. Midcareer Investigator Award In Patient-Oriented Research (K24)
<javascript:popWindow('http://grants1.nih.gov/grants/guide/pa-files/PA-04-10
7.html')>
http://grants1.nih.gov/grants/guide/pa-files/PA-04-107.html
PAR-04-112. Reducing Mental Illness Stigma And Discrimination
http://grants.nih.gov/grants/guide/pa-files/PAR-04-112.html
RFA-MH-05-003. Cooperative Drug Development Group (Cddg) For The Treatment
Of Serious Mental Illness
http://grants1.nih.gov/grants/guide/rfa-files/RFA-MH-05-003.html
http://grants1.nih.gov/grants/guide/rfa-files/RFA-MH-05-003.html
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